PREMATURITY AND MATERNAL HEALTH CONDITIONS INFLUENCE ON PLASMA GLUCOSE AND TRIGLYCERIDE LEVELS IN NEWBORNS AT SIX MONTHS OF CORRECTED AGE

Code: 210805675
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Título

PREMATURITY AND MATERNAL HEALTH CONDITIONS INFLUENCE ON PLASMA GLUCOSE AND TRIGLYCERIDE LEVELS IN NEWBORNS AT SIX MONTHS OF CORRECTED AGE

Autores(as):
  • Bruna Juliana Zancanaro Frizon

  • Grasielly Masotti Scalabrin Barreto

  • Hugo Razini de Oliveira

  • Ana Tereza Bittencourt Guimarães

  • Claudia Silveira Viera

  • Beatriz Rosana Gonçalves de Oliveira Toso

  • Talita Bavaresco

  • Álvaro Largura

  • Sabrina Grassiolli

DOI
  • DOI
  • 10.37885/210805675
    Publicado em

    01/12/2021

    Páginas

    294-306

    Capítulo

    22

    Resumo

    In the present study we evaluated growth, glucose and lipids homeostasis in preterm (PT) infants at birth and at 6 months of corrected age (6m of CA) and correlated with maternal health conditions. This was a longitudinal prospective study conducted between May 2015 and February 2017 with PT (n=71) and full term (FT) infants(n=82) and their respective mothers in a public hospital at south of Brazil. At birth, PT-infants showed, reduced growth parameters, high levels of glucose, insulin but lower triglyceride levels when compared to FT-infants. Only glucose remained elevated in PT-infants at 6m of CA; an effect correlated significantly with higher maternal body weight gain and with high degree of prematurity. In contrast, elevated maternal insulin plasma level was correlated with smaller glycemia of PT-infants at 6 m of CA. Moreover, in association, elevated maternal body weight gain during pregnancy, greater values of plasma glucose, insulin and cholesterol and high degree of prematurity were positively correlated with high plasma triglyceride levels in PT-infants at 6 m CA. In conclusion, this study confirms that maternal body weight gain and their metabolic state, as well as, the degree of prematurity are elements that affect glycemia and trigliceridemia in PT infants at 6 m CA. Glucose and lipid homeostasis at birth and infancy can determine onset of chronic diseases in adult life. Thus, PT-infants and their mothers should be more strictly accompanied to preserve health in future.

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    Palavras-chave

    Pregnancy, Prematurity, Glucose, Lipids, Metabolic Programming.

    Licença

    Esta obra está licenciada com uma Licença Creative Commons Atribuição-NãoComercial-SemDerivações 4.0 Internacional.

    Licença Creative Commons

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