IMPACT OF PRENATAL LIPOPOLYSACCHARIDEEXPOSURE ON THE DEVELOPMENT OF RATS
Marina Goulart da Silva
Silva, Marina Goulart da
Guilherme Cabreira Daros
Daros, Guilherme Cabreira
Gabriela Mazzuco dos Santos
Santos, Gabriela Mazzuco dos
Isabella Paes Angelino
Angelino, Isabella Paes
Rafael Mariano de Bitencourt
Bitencourt, Rafael Mariano de
Jucélia Jeremias Fortunato
Fortunato, Jucélia Jeremias
01/06/2021
147-165
12
The intrauterine environment is infl uenced by several factors, genetic or environmental, which are essential in understanding the pathophysiological mechanisms of some diseases. In this study, the aim was to investigate the impact of prenatal lipopolysaccharide exposure on the development of rats. Fifty pregnant rats received intraperitoneal administration of lipopolysaccharide (100 μg/kg), or saline at the same dose, on the 9.5th day of pregnancy. The offspring of these rats were analyzed for indicators of brain and somatic development and maturation of physical characteristics. Refl ex ontogenesis was also analyzed by vibrissae placement, negative geotaxis, palmar grasp, precipice aversion, decubitus recovery and acceleration reaction. Administration of lipopolysaccharide on the 9.5th gestational day caused delayed opening of the auditory pavilion, reduction in the length of the tail, body, cranial axes, and body weight. Thus, maternal infections can interfere in the intrauterine environment, impairing functional and structural aspects of the central nervous system, as well as the maturation of physical characteristics.
Developmental disorders; Immune system; Lipopolysaccharide; Somatic development; Sensory motor development.
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