EVALUATION OF DIFFERENT METHODS USED FOR DIAGNOSIS OF INFECTION BY TOXOPLASMA GONDII IN PREGNANT WOMEN.

Toxoplasmosis is a worldwide distribution zoonosis that can infect a wide variety of animal and human species. It is caused by the protozoan Toxoplasma gondii, which causes silent disease. Neonates with congenital toxoplasmosis may exhibit neurological manifestations, ophthalmic lesions, hearing impairment, and even death after birth. Thus, during the gestational period, periodic monitoring through laboratory diagnoses is of great importance for the well-being of the fetus. Pregnancy-associated toxoplasmosis is of great importance to public health due to its prevalence and severity of congenital cases. The present study aimed to detect antibodies of the IgM and IgG class T. gondii in pregnant women treated at Hospital das Clínicas, FMB Unesp, Botucatu campus. The results of serology were evaluated by the technique of Indirect Immunofluorescence Reaction (IFAT) and Microparticle Immunoassay with Chemiluminescence (QL). The results were evaluated according to the variables studied, such as age, profession, race, among others, and the results in different types of diagnosis in pregnant women. Results obtained in the Microparticle Immunoassay with Chemiluminescence test with the other serology tests, with the QL being adopted as the gold standard. The results found show a strong correlation in the QL and RIFI techniques for IgG immunoglobulin and a weak correlation for IgM immunoglobulin. The most frequent titles were 16, 64, 256 and 1024. It was concluded by the importance of the diagnosis performed at the beginning of the infection for prevention, and care indicated for the pregnant woman and the fetus. It is noteworthy that with early diagnosis in prenatal care, transmission to the neonate can actually be avoided, in addition to reducing complications in congenital transmission.