ESSENTIAL OIL FROM EUGENIA PYRIFORMIS CAMBESS AERIAL PARTS AND ITS MAJOR CONSTITUENT LIMONENE AS AN AGENT WITH ANTI-ACETYLCHOLINESTERASE AND ANTICARIOGENIC ACTIVITIES

Code: 230613489
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Título

ESSENTIAL OIL FROM EUGENIA PYRIFORMIS CAMBESS AERIAL PARTS AND ITS MAJOR CONSTITUENT LIMONENE AS AN AGENT WITH ANTI-ACETYLCHOLINESTERASE AND ANTICARIOGENIC ACTIVITIES

Autores(as):
  • Cassia Cristina Fernandes

    Fernandes, C. C.

  • Mariana Brentini Santiago

    Santiago, M. B.

  • Carlos Henrique Gomes Martins

    Martins, C. H. G.

  • Jackson Breno Amaral Silva

    Silva, J. B. A.

  • Antônio Eduardo Miller Crotti

    Crotti, A. E. M.

  • Mayker Lazaro Dantas Miranda

    Miranda, M. L. D.

DOI
10.37885/230613489
Publicado em

31/08/2023

Páginas

510-522

Capítulo

43

Publicado no livro

OPEN SCIENCE RESEARCH XII

Resumo

This study aimed at determining, for the first time, anticariogenic and anti-acetylcholinesterase activities of essential oil from Eugenia pyriformis aerial parts (EP-EO) and its major constituent limonene against cariogenic bacteria and the enzyme acetylcholinesterase (AChE). EP-EO and limonene were subject to the broth microdilution method on 96-well microplates and determination of minimum inhibitory concentration (MIC) and minimum inhibitory concentration of biofilm (MICB50) (µg/mL). AChE inhibition was qualitatively evaluated by Thin Layer Chromatography (TLC). EP-EO and limonene not only showed strong anticariogenic activity, since their MIC and MICB50 values ranged between 20 and 400 µg/mL, but also inhibited cholinesterase when subject to TLC. Both GC-MS and GC-FID analyses identified and quantified the following major constituents: limonene (14.8%), nerolidol (11.0%) and α-cadinol (10.3%). This study showed that EP-EO and limonene were active in in vitro assays and, thus, may be important targets of further in vivo studies.

Palavras-chave

tooth decay, Alzheimer’s disease, acetylcholinesterase, Streptococcus mutans, limonene.

Autor(a) Correspondente
Licença

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